Hegewisch S, Bressler J, Haimi J, Souza L, Welte K, Andreeff M
The anti-inflammatory effect of choline was confirmed ex vivo, where endotoxin-activated human whole blood and macrophages exposed to supraphysiological choline concentrations (between 150 mM) exhibited reduced TNF- production (250)
These findings, together with comparative structure analysis, time-lapse microscopy, and phosphoproteomics, reveal unique signaling signatures for GLP-1R agonists at the level of receptor conformation, functional selectivity, and location bias, thus associating signaling neighborhoods with functionally distinct cellular outcomes and clinical consequences
Clinical application of DNA/RNA flow cytometry in adult leukemia
M., Pina-Camacho, L., Moreno, C., Durn-Cutilla, M., Ayora, M., Gonzlez-Vioque, E., De Matteis, M., Hendren, R