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Phase 3 development of semaglutide in AD was supported by converging evidence from preclinical models, real-world datasets, and post hoc cardiovascular trial analyses, including a target trial emulation of electronic health records from more than 1 million patients with type 2 diabetes showing a 40% to 70% lower risk of first-time AD diagnosis with semaglutide compared with other antidiabetic medications, including other GLP-1 receptor agonists
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