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Core muscle strength may not immediately adapt to changing body composition, potentially causing increased mechanical stress on the lumbar spine, though this mechanism remains hypothetical for pharmacologic weight loss

Obesity Prevalence and Treatment Paradigm Shift: With over one billion people globally living with obesity and only a fraction receiving pharmacotherapy, the addressable market dwarfs diabetes alone [1]

It provides effective relief from pain, inflammation, and fever by inhibiting cyclooxygenase (COX) enzymes, which are responsible for producing prostaglandinschemical mediators of inflammation and pain

However, the medications mechanisms of action can indirectly influence hormonal balance, potentially affecting the menstrual cycle in some individuals

Clinical trials have demonstrated average weight loss of 1215% over 68 weeks with semaglutide 2.4 mg weekly