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Importantly, bortezomib has shown promise in refractory SLE patients, 540,541 emphasizing the translational relevance of proteasome modulation in severe autoimmune disease
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But the peptide is pharmacologically inactive
Going back to the IEL cells for a moment, in Crohns disease and ulcerative colitis (UC) these cells can start to attack the gut lining itself, this further creates a cytotoxic environment, which can further exacerbate IELs to produce pro-inflammatory proteins, this can lead to a compromised intestinal lining, along with alterations in the gut microbiome
Another 2023 study in the Journal of the Endocrine Society this one a 12-week clinical trial found that smokers taking the GLP-1 drug dulaglutide drank less alcohol than those who took a non-acting placebo
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