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Mechanism of Action Melanotan II binds and activates melanocortin receptors via a cyclic lactam backbone that confers significantly greater receptor affinity than the native -MSH linear sequence
This ingredient has been found safe as used in cosmetics with low irritation risk
in preclinical and in-vitro systems it has been studied as a GHRH-receptor agonist on anterior pituitary cells, where it has been observed to stimulate the synthesis and pulsatile release of endogenous growth hormone
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