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In male rats, a HFD (G0-P21) reduced POS-induced cognitive impairments as measured in the MWM at M4-7 [137] and the conditioned odor preference (COP) at M6 [141]
Loss of Lean Mass Weight loss, achieved through a calorie-reduced diet, which may or may not involve the use of GLP-1 agonist drugs, decreases both fat and lean body mass
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Sleep disruption can also play a major role
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