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When clinics prescribe the combination, AOD-9604 is typically dosed at 250 to 500 mcg daily by subcutaneous injection, sometimes given in the morning on a fasted basis based on the theory that lipolysis is more active during fasting

Clinical Evidence for Semaglutide and Anti-Inflammatory Effects The SUSTAIN-6 trial (2016) in patients with type 2 diabetes demonstrated that semaglutide reduced major adverse cardiovascular events, a benefit often attributed to both glucose control and reduced vascular inflammation

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