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A study conducted in 2016 thus came to the following conclusion: If we had restricted the treatment of symptomatic patients to patients with both low serum levels and elevated metabolite levels, 63% of patients who responded well to the therapy would not have received treatment [] Only 16% of patients with good clinical improvement from vitamin B12 therapy had low serum levels and 54% of patients with good clinical improvement from vitamin B12 therapy had serum levels higher than 300 pg/mL. Some experts thus advise high-dose B12 treatment to treat all known nervous symptoms associated with B12 deficiency

As we get better at treating B12 deficiency, were giving our patients the best care possible

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## **Other relevant codes** Other relevant HCPCS codes related to HCPCS Q5123 (Injection, rituximab-arrx, biosimilar, Riabni 10 mg) include codes for other rituximab biosimilars and related biologic drugs: - Q5115: Injection, rituximab-abbs, biosimilar, 10 mg (Truxima) - Q5119: Injection, rituximab-pvvr, biosimilar, 10 mg (Ruxience) - J9312: Injection, rituximab, 10 mg (reference rituximab drug) - J9311: Injection, rituximab 10 mg and hyaluronidase (combination product) - J3590: Unclassified biologics (used sometimes for unspecified biologics) - Q5122: Injection, pegfilgrastim-apgf, biosimilar, 0.5 mg - Q5124: Injection, ranibizumab-nuna, biosimilar, 0.1 mg Frequently asked questions