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Some legal filings cite studies suggesting the risk could be significantly higher for patients who have been on the medication for longer than 1.5 years
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Elevated levels of 3indoleacetic acid (IAA) (Fig
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This phenomenon was first described by Lemasters group [37] when APAP-induced MPTP opening and necrotic cell death in primary isolated hepatocytes was attenuated by MPTP inhibitors at early time points but not late time points where caspase activation was detected
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