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Gao L, Lee BW, Chawla M, Kim J, Huo L, Du L, et al

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), constitute an escalating worldwide health challenge, with prevalence estimates reaching one-quarter of adults globally

Incretin mimetics are particularly suitable for: Patients where weight loss would provide additional health benefits Individuals at high cardiovascular risk who may benefit from the cardioprotective effects of certain agents (liraglutide, semaglutide, dulaglutide) Patients wishing to avoid or delay insulin therapy Those requiring substantial HbA1c reductions to reach target levels NICE NG28 specifies continuation criteria for GLP-1 receptor agonists in triple therapy: continue only if there is a beneficial metabolic response, defined as a reduction of at least 11 mmol/mol (1.0%) in HbA1c and weight loss of at least 3% of initial body weight at six months

However, it's important to check with a healthcare professional to tailor your supplement stack to your individual needs and goals

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