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The distinctive morphological changes associated with ferroptosis include mitochondrial shrinkage, a reduction in or disappearance of mitochondrial cristae, and increased mitochondrial membrane density [13]

The use of chelators may improve the therapeutic efficacy compared with the use of platinum-based chemotherapeutic agents (111)

Participants Participants were recruited from April 2017 to September 2019 from the Greater Kansas City area via printed flyers, research opportunity advertisements to the community, social media advertisements, and targeted registry mailings (Figure 1)

10.1038/ki.2015.332 93 SalahudeenA

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