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For peptide therapeutics, the pharmacokinetic impact of liver disease differs from that of small molecules
PT-141 Injections vs
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Some studies have shown that when combined with nitrites, potassium sorbate have genotoxic activity in vitro
However, a separate Phase 3 study in paediatric patients showed clinically meaningful overall survival, prompting AstraZeneca to proceed with regulatory submissions for the paediatric indication while continuing discussions with health authorities regarding the adult program
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