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BMI of 27+ (Overweight): Individuals with at least one weight-related condition, such as hypertension (high blood pressure), dyslipidemia (high cholesterol), or pre-diabetes

Alcohol dehydrates and can slow gut motility, worsening constipation through multiple mechanisms

The reason: retatrutide doses reach 12 mg per week at maximum maintenance, compared to 15 mg for tirzepatide and 2.4 mg for semaglutide

doi: 10.1073/pnas.1607235113 78 HayashiTFujitaKNojimaSHayashiYNakanoKIshizuyaYet al