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Previously, the GLP-1R agonist liraglutide has been shown to attenuate EMT changes in the UUO model by inhibiting TGF-1/Smad3 and ERK1/2 signaling pathways ( The present study in kidney transplantation model also indicates that TB001 significantly enhances lipid metabolism (marked by increased CPT1A expression in TECs) and reduces PKC- and PKC- expression, thereby attenuating kidney allograft fibrosis
Brain 139:306309
doi:10.1056/NEJMoa2032183 2Wilding JPH, Batterham RL, Calanna S, et al
Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study
Dring, J
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