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MIC19 is not only a key member of mitochondrial cristae junctions, responsible for the organisation of mitochondrial inner and outer membrane contacts, as well as for the architecture of respiratory complexes and the mitochondrial proton pump, but also plays a prominent role in ERMCSs, where it enables the transfer of lipid precursors for the biosynthesis of the key mitochondrial lipid cardiolipin 68 , therefore connecting mitochondrial cristae organisation with the generation of membrane curvature and control of mitochondrial function afforded by cardiolipin 11
It supports the stability of the liposomes and allows for an extended shelf life
J Biol Chem (2006) 281(45):3412434
These molecules use chemical cross-links to stabilize peptide structure and improve cell permeability while maintaining biological activity
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