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Conceptualization, Funding acquisition, Supervision, Writing-review & editing Acknowledgments We thank the high-field NMR facility at the Korea Basic Science Institute (KBSI, Ochang) and the GIST Advanced Institute of Instrumental Analysis (GIST, Gwangju) for allowing us to use their NMR spectrometers

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Research has revealed that GPER activation induces AKT phosphorylation, which promotes osteoblast proliferation and differentiation, indirectly supports vitamin D metabolism and contributes to skeletal integrity [112]

and, finally, as a carbon source for epigenetic regulation, biomass production and energy production

2 Table 2 Clinical Manifestations of Vitamin B12 Deficiency Maternal vitamin B 12 deficiency during pregnancy or while breastfeeding may lead to neural tube defects, developmental delay, failure to thrive, hypotonia, ataxia, and anemia