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Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine

GLP-1s and Existing Underactive Thyroid (Hypothyroidism) While the cancer risk is the most talked-about "thyroid issue," a more common practical concern involves how GLP-1s affect those already taking medication for an underactive thyroid, such as levothyroxine

Patients who started tirzepatide but discontinued before reaching 10 mg lost 8.1% of baseline weight

Other contributing factors include cardiovascular disease, obesity, polypharmacy, and psychological factors, all of which are common in patients prescribed tirzepatide

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