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Proper storage, preparation, and IV administration technique are essential for glutathione stability, as the tripeptide is highly susceptible to oxidation in solution

Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)

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Ann Neurol 1994

Moreover, regarding that GSH is critical in DNA synthesis, while DNA damage is correlated with UC, we can conclude that lycopene exerts its beneficial effect on UC by preventing oxidative-related DNA damage (Yin et al., 2023