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besides, due to its extremely low affinity for C1q complement components, IgG4 cannot trigger the complement cascade via the classical pathway ( in vivo , and in vitro measurements of pathogenicity have confirmed that MuSK antibodies do not alter pathogenicity by FAE with IgG4 from healthy sera, implying that monovalent IgG4 is sufficient to induce pathogenicity (Koneczny et al., 2017)
UIDP/00215/2020 (DOI: 10.54499/UIDP/00215/2020)
Carlstrom, M
Wharton S, Konig M
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