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GIP is produced and secreted into the blood by K cells located in the mucosa of the upper gastrointestinal tract's duodenum and upper jejunum while GLP1 is produced and secreted into the blood by L cells located in the mucosa of the lower gastrointestinal tracts small and large intestines

Lancet Psychiatry 2020;7(1):52-63 Chang CK et al

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Side effects can be greatly mitigated by reducing dietary fat, consuming smaller portions, and not skipping meals, Kushner says