Oral supplements have to pass through the digestive system and may not be absorbed efficiently, especially in people with gastrointestinal conditions like celiac, Crohns, or gastritis
Vitamin B12 injections begin working at a cellular level almost immediately after administration, though the timeframe for noticeable symptom improvement varies considerably between individuals
You should also contact your GP if: You are unable to attend scheduled maintenance injections, as missing doses can lead to symptom recurrence You develop new symptoms that might indicate other deficiencies or health problems You are planning pregnancy, as B12 requirements may change You experience persistent side effects such as headaches, dizziness, or gastrointestinal symptoms If you experience any side effects, talk to your doctor, pharmacist or nurse
One study reported that vitamin B12 deficiency was associated with twice the risk of severe depression (4)
B12 injections bypass the gut