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The therapeutic mechanisms of these natural products have been summarised, including direct regulation of McSCs, melanin production, melanin transport, and related signalling pathways such as the cAMP/PKA and MAPK signalling pathways

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In the resting state, MPO contains iron in oxidation state 3 + (MPO-Fe(III)), and in the course of the peroxidase cycle, H 2 O 2 interacts with the Fe(III) heme center, supported by hydrogen bonds with the H 2 O molecule and histidine95

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