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Int Rev Immunol
This dosage range has been shown to be effective in clinical studies and sits well within the established safety margins
In a recent investigation undertaken by our group, adult mice with partial IGF-1 showed a decrease in the expression of genes involved in glucose metabolism (phosphoenolpyruvate carboxylase-1, glucose-6-phosphatase, pyruvate dehydrogenase kinase isoenzyme-4, and ATP-citrate lyase), resulting serious hyperglycaemia [164]
Low-Moderate = robust animal data, no human RCTs
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