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NICE guidance on the assessment and management of overweight and obesity in adults (currently CG189 and associated updates) provides the overarching framework, alongside the technology appraisals for semaglutide 2

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9F) confirmed significant enrichment of Pseudomonadota and depletion of Bacteroidota in the VPA-ASD model

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The broader guide on tirzepatide and autoimmune disease provides additional context