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Per week: 21 syringes (3/day 7 days) 12 weeks: 252 syringes recommend 3 100count boxes Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial for reconstitution

Each steady-state period ended with a 24-h on-site PK sampling visit (visits 5, 7, 9 and 11) before proceeding to the next steady-state period (or follow-up)