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This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses

Molecular Interventions

Stress, poor sleep, medications, infections, alcohol, aging, and even intense workouts can deplete your glutathione levels faster than your body can replenish them

DSIP is studied for a possible role in deep sleep, but decades of research have not established a clear, reliable clinical effect, so it remains investigational

2020;54:44754.e4