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8 Reasons for less weight loss with GLP1 RAs for T2D could include use of insulin or other obesity-promoting medications, concerns over hypoglycemia, decreased glycosuria, microbiome variation, genetic predisposition towards weight gain, and differences in endogenous GLP-1 pathways in the brain and other tissues
in 2017, while Mounjaro, Ozempics primary competitor, was approved in 2022
For each study included in the review, we extracted detailed information on the study design, sample size, participant characteristics, type and dosage of GLP-1 RA used, and the key outcomes measured
A dose taken with imperfect timing is always better than a dose not taken at all
In contrast, pens for long-acting insulin, used once or twice daily, have fewer portability requirements, although similar devices are often used for both
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