This is harder to quantify but worth noting
Another study indicated that overexpression of FTO increased autophagy related 5 homolog (ATG5) protein expression at low m 6 A levels, reduced PKM2 expression levels, and decreased mitochondrial ATP production in ectopic endometriotic stromal cells [190]
During the randomized treatment period, patients received a standard lifestyle instruction every 12 weeks on reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND or placebo and continued throughout the 72-week treatment period
Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS et al (2014) Regulation of ferroptotic cancer cell death by GPX4
GLUTATHIONE Glutathione (GSH) works through several key biochemical mechanisms, primarily centered on the reactive sulfhydryl group on its cysteine component