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Inactivation of -catenin, by contrast, results in dramatically reduced proliferation of hair progenitor cells and premature induction of the catagen (destructive) phase
Fox RJ, Gold R, Phillips JT, Okwuokenye M, Zhang A, Marantz JL
In the multicenter PIVENS ( PI oglitazone versus V itamin E versus placebo for the treatment of N onalcoholic S teatohepatitis) trial, 247 subjects with MASH but not diabetes mellitus were randomized to receive 30 mg/day of pioglitazone (an insulin-sensitizing drug), 800 IU/day (536 mg/day) of RRR --tocopherol, or a placebo for 96 weeks (97)
Therefore, a high amount of pheomelanin must be present for a lighter skin tone, and eumelanin should be less concentrated
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