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Janus kinase (JAK) blocker Tofacitinib, a JAK blocker, accelerated bacterial elimination in a preclinical study when administered at high doses alongside standard TB chemotherapy in chronic M.tb -infected BALB/c mice

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In adults and older children, the total volume used should also stay within safe limits animal studies suggest up to about 30 mL (the full vial) can be given to an adult without benzyl-alcohol toxicity, but one should still use only the amount needed and discard the rest if sterility is lost

These unfolded/misfolded proteins remain within the endoplasmic reticulum (ER) lumen leading to excessive ER stress which is detrimental for cell survival 7