During perimenopause and menopause, estrogen and progesterone levels shift
For individuals considering either compound, understanding the biochemical differences, clinical evidence, and personal biomarker context becomes essential before provider consultation
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You cannot feel the needle enter the skin, so theres nothing to be afraid of for the injection, and so once people get beyond that issue, I think a lot of people will really enjoy the once-weekly option over taking a tablet every day. Indeed, Van Spall said, the once-weekly dose can be easier to adhere to, so switching to the daily oral dose may require efforts to ensure adherence. What to Watch Out for When Switching Van Spall and McGuire gave some guidance around how to switch patients between therapies if needed
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you can also search for UK trials via NIHR Be Part of Research (www.bepartofresearch.nihr.ac.uk) Do not discontinue any existing prescribed medication (such as semaglutide or tirzepatide) in anticipation of retatrutide becoming available For clinicians: Familiarise yourself with the LY3437943 development code and ongoing Phase 3 trial data, as patients may present with questions informed by media coverage Be prepared to discuss the distinction between investigational and approved therapies , and the importance of evidence-based prescribing Monitor MHRA and NICE communications for updates on regulatory submissions and technology appraisals From a safety perspective, the adverse effect profile observed in Phase 2 trials (as reported in the 2023 New England Journal of Medicine publication) was broadly consistent with other GLP-1-based therapies, with nausea, vomiting, diarrhoea, and decreased appetite being the most commonly reported side effects