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The concern about kidney load is more commonly associated with peptides that stimulate significant systemic hormone production or with impurities in research-grade sources
[7] Centers for Disease Control and Prevention
Proper screening helps rule out conditions where B12 shots may not be appropriate or when dosing needs adjustment
Animal studies show no toxicity even at doses 1,000 higher than typical use, but that doesn't mean high doses are risk-free in humans (Sikiric et al., 2014)
But, it actually contains B12 analogues which are often confused with vitamin B12
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