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Consistent with this TFEB-dependent remodeling of the endolysosomal system, zinc also induces the expression of lysosomal proteases, including cathepsins B and D, thereby enhancing lysosomal proteolytic capacity 103
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Triple-agonist compounds such as RETA are studied to explore whether simultaneous pathway engagement produces distinct signalling patterns compared to more limited receptor activation
Cardiovascular benefits have been demonstrated specifically for dulaglutide in the REWIND trial, showing that the medication can reduce major adverse cardiovascular events in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors
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