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Downstream IGF-1 and IGFBP-3 Signaling After being released into circulation, growth hormone acts on receptors in multiple peripheral tissues, including the liver, skeletal muscle, bone, and adipose tissue. One of its major downstream effects is stimulation of insulin-like growth factor 1 production
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Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca 2+ signaling via glucagon receptors
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