activation glp-1 Glucagon-like peptide-1 receptor: mechanisms and advances in therapy The Generation and Function of

Yes, and actually nausea is the most commonly reported side effect of taking Semaglutide

In contrast, a recent meta-analysis 55 synthesizing randomized and observational data did not find a significant association between GLP-1 RAs and suicide or self-harm outcomes

Post-sleeve gastrectomy body-composition research: Role of botulinum toxin and [PMID: 41777326] Laboratory literature summary: Post-sleeve gastrectomy body-composition research: Role of botulinum toxin and semaglutide parenteral-route administration

So, the modest improvement in depression seen in the study may be related to weight loss, improved blood sugars, [fewer diabetes] symptoms, and likely an overall sense of patients getting healthier.

GLP's effects appear agnostic to SUD diagnosis or substance