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Semaglutide 2 4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
Both of these events lead to a reduction in contraction which, when coupled with the initial increase in contraction, allows for faster cycling and consequently higher heart rate with increased contractility
Fatigue that persists beyond the initial titration phase warrants investigation for other causes, including nutritional deficiencies common in bariatric patients
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