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Quick answer: L-carnitine is most plausible for people with a real carnitine deficit or a context where trials show bigger effects: older adults, people with overweight or obesity, some metabolic-health populations, dialysis patients under medical care, and athletes using it for recovery over weeks, not days

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Efficacy and safety of semaglutide 2.4 mg for weight loss in overweight or obese adults without diabetes: An updated systematic review and meta-analysis including the 2-year STEP 5 trial

See the Update to our Probiotics Review for details, including our take on this