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In PD, reduced REM density is associated with impaired gait and motor ability and can be influenced by sustained-release dopaminergic medications in the evening, suggesting that the REM-related sleep alterations reflect neuroregulation abnormalities beyond motor function [159]

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In obese T2DM patients, exenatide reduced putamen activity to high-calorie food pictures, while enhancing putamen responses to low-calorie food pictures [39,40]

Fourth, although the sample size achieved the necessary statistical power to support the results, future studies should include larger sample sizes to analyze cohorts and corroborate the directions of the present findings

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