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Electrostatic potentials for ScGrx6 and ScGrx7 were computed and mapped to the protein surface using the PoissonBoltzmann method of Swiss-PDB Viewer (dielectric constant solvent: 80, atomic partial charges, dielectric constant protein: 4, solvent ionic strength: 0.1 M)
It's a complementary mechanism, not a standalone solution
These complementary mechanisms suggest potential synergy
Novo Nordisk developed it as a long-acting version of the naturally occurring hormone, engineered with specific amino acid substitutions that extend its duration of action from minutes to days
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