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Understanding the distinct and complementary contributions of each receptor system is essential to appreciating how mono-, dual-, and triple agonist formulations achieve their therapeutic effects [7-9,18,19] [Figure 1 and Table 1]
The wave of semaglutide medications on the market comes as brand-name injectable versions like Ozempic and Wegovy or oral medications like Rybelsus
Stopping abruptly may cause rebound appetite and weight regain
Increased GH and IGF-1 may indirectly modulate gonadotropins and sex steroids to support ovulation and spermatogenesis, so track LH, FSH, testosterone, estrogen, progesterone, and SHBG to assess response
Risk of bias assessment Assessment of publication bias for suicidal thoughts and dizziness associated with tirzepatide showed no significant asymmetry in funnel plots
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