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Nausea, vomiting, diarrhea, stomach pain, and constipation, especially in the first weeks as your body adjusts
A 2023 study published in Frontiers in Endocrinology found that certain plant polyphenols can naturally stimulate GLP-1 secretion and enhance insulin sensitivity showing that nature already has safe ways to activate these pathways
Zhang Y, Wu M-J, Lu W-C, Li Y-C, Chang CJ, Yang J-Y
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The most widely used ones right now are semaglutide (sold as Ozempic for diabetes management and Wegovy for weight loss) and tirzepatide, which targets both GLP-1 and a second hormone called GIP (Mounjaro for diabetes, Zepbound for weight loss)
