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These programs can provide behavioral counseling, pharmacologic optimization, and relapse prevention strategies

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This shift is coupled to significant changes in mitochondrial morphology, reactive oxygen species (ROS) production, and metabolically driven epigenetic changes that ultimately determine NSC/NPC fate (Figure 2)

Two distinct pathways lead to microbial conversion of phenylpyruvic acid to phenylacetic acid (PAA) 35

Starting low and escalating gradually produced fewer gastrointestinal side effects than starting directly at a higher dose, which is why the 2mg +2mg-every-4-weeks schedule became the standard escalation approach in the published data