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Second, metabolic anaplerosis and nutritional interventions have relatively strong operability in mucosal immunity and chronic inflammatory settings

CULLIN-RING ligases (CRLs) are the largest family of E3 ubiquitin ligases in eukaryotes, utilizing CULLIN proteins (CULLIN1, 2, 3, 4 A, 4B, 5, 7, 9) as scaffolds 5

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Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)