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What the Phase 3 doses tell us The Phase 3 maintenance doses of 4mg, 9mg, and 12mg represent a refinement of the Phase 2 protocol
Although many of these effects were reversible after a withdrawal period, they highlight the potential risks of prolonged or high-dose PPR use
In the first step, glutamate and cysteine are ligated by -glutamylcysteine synthetase (also known as glutamatecysteine ligase, GCL) to form -glutamylcysteine, utilizing one molecule of ATP
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After a minimum of 30 days at this initial dosage, it can be increased to 7 mg once daily if additional glycemic control is required
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