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This oxidative stress, in turn, triggers a cascade of detrimental cellular responses, including the release of pro-inflammatory factors [160]

But when weight loss occurs rapidly particularly without adequate nutrition and physical activity individuals may lose not only fat, but also lean muscle mass and bone density

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Precisely at the core of the central gain model is the hypothesis that extensive spontaneous and sound-evoked neuronal hyperactivity in higher auditory structures (e.g., DCN) may constitute a key neural correlate underlying the sound percepts of tinnitus 46,47,48,49