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In order to generate this model and induce PCOS-like traits in adult offspring, pregnant dams were administered with a daily dose of the androgen dihydrotestosterone (DHT, 250 g/day) during gestational days 16, 17, and 18

Then, -ketoglutarate can enter back into the TCA for completing the cycle

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The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability

Operating from July 1, 2026, through December 31, 2027, this temporary initiative acts as a "bridge" to a future, permanent Medicare model (the BALANCE Model)