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Henningsson RAP, Lundquist I: Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia
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Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016
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