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*Correspondence: Keizo Kanasaki, [email protected] Daisuke Koya, [email protected] This article was submitted to Gastrointestinal and Hepatic Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

It also boosts metabolism, helping the body burn calories more efficiently

GLP-1 signaling enters this scheme as a regulator that reduces maladaptive reward salience while improving mitochondrial and neuronal resilience

A compound with an electrophilic center forms a GSH conjugate in a reaction catalyzed by GSH S-transferase

These new agents aim to offer enhanced tolerability and minimize adverse events compared to traditional treatments