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The approval matters because it validates a long-sought oral small-molecule route to GLP-1 agonism, with potentially major consequences for convenience, manufacturing scale, pricing, and patent strategy

poor statin adherence reduced mortality by 35% and that discontinuation increased mortality risk by 90%

Stimulating GLP-1R in BMSCs triggers the buildup of nuclear -catenin, which, in turn, activates osteogenic genes by binding with TCF7L12

What started as a market barely worth $1 billion in 2020 is now on track to hit a staggering $100 billion by 2030