GLP-1s are not approved to treat symptoms of menopause and do not replace existing approved therapies
After doing a comprehensive evaluation and discussing the potential benefits and drawbacks, our medical team develops a customized treatment plan that incorporates these medications with lifestyle modifications like maintaining a balanced diet and engaging in regular exercise
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Dietary Modifications Adjusting your diet can substantially reduce digestive discomfort: Eat smaller, more frequent meals rather than large portions, which accommodates the delayed gastric emptying Reduce dietary fat intake , particularly saturated fats, as these are more difficult to digest when stomach emptying is slowed Avoid spicy, heavily seasoned, or fried foods that may exacerbate nausea or diarrhoea Increase soluble fibre gradually (oats, psyllium, fruits) if experiencing diarrhoea, as this helps bulk stools Stay well hydrated , consuming at least 1.5-2 litres of water daily, especially if experiencing loose stools (note: adjust fluid targets if you have heart failure or chronic kidney diseaseconsult your healthcare provider for personalised advice) Limit alcohol and caffeine , both of which can irritate the digestive system Timing and Dose Escalation According to the BNF and SmPC, Ozempic is initiated at a low dose (0.25 mg weekly) specifically to minimise gastrointestinal side effects

Figure 3 Locally produced melatonin also protects the intramitochondrial environment from oxidative stress since in addition to acting as a direct radical scavenger it also stimulates enzymes, i.e., superoxide dismutase 2 (SOD2) and glutathione peroxidase (GPx), that remove ROS from the mitochondrial matrix (103)